HEPATITIS C. VIRAL INFECTION IN PATIENTS WITH NON-HODGKIN LYMPHOMA

*Khldoun Salah Aslan

ABSTRACT

Background: Lymphoma is considered a serious disease with an increased prevalence , so it was necessary to research all its possible causes, including HCV infection, to search for new treatments and prevention methods. This study is the first of its kind in Syria to investigate the relationship between HCV infection and the occurrence of lymphoma,. Numerous studies have proven that the correct treatment of HCV infection in patients with some types of lymphoma significantly improves the prognosis and therefore the detection and treatment of HCV is extremely important. The aim of the study: Measurement of the level of HCV antibodies in patients with non-Hodgkin Lymphoma and comparison with two groups (healthy people, patients with solid tumors) in order to study the possible relationship between Hepatitis C and lymphoma. Materials and Methods: This study was conducted at Tishreen University Hospital, Syria between 2023-2024. Serological samples were collected for three groups: the first group consists of 58 patients with all types of non-Hodgkin lymphoma, the second group consists patients with solid tumors (64 patients), and the third healthy group (61 people). After separated the hematogram using a micropipette and transferred it to the Eppendorf tubes, Direct ELISA technique was used to detect anti HCV IgG. Results: The study sample included 58 patients, 50 patients were negative in hepatitis C Virus Antibodies ( 86.2%) , while the number of positive patients were 8 patients by (13.8%). We can say that there is an association between Hepatitis C infection and non- Hodgkin lymphoma, but we cannot say for sure that HCV infection will inevitably lead to non- Hodgkin Lymphoma.

Keywords: Non-Hodgkin Lymphoma, Hepatitis HCV, ELISA, Antibodies.