EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

UNVEILING HOPE: REVERSIBLE ALCOHOLIC FATTY LIVER DISEASES – A COMPREHENSIVE REVIEW

M. Naveena*, Kammari Anusha, Thota Rahul, Siramdas Nikitha and Kammati Pavani

ABSTRACT

Reversible Alcoholic Fatty Liver Disease (AFLD) represents a significant health burden globally, with its prevalence rising steadily. AFLD encompasses a spectrum of liver conditions, ranging from hepatic steatosis to more severe forms such as steatohepatitis and fibrosis, ultimately leading to cirrhosis if left untreated. Understanding the mechanisms underlying AFLD pathogenesis is crucial for developing effective therapeutic interventions. This review provides an overview of the etiology, pathophysiology, and risk factors associated with AFLD. The intricate interplay between alcohol metabolism, lipid metabolism, oxidative stress, inflammation, and genetic factors contributes to AFLD progression. Additionally, lifestyle modifications, including alcohol cessation, dietary changes, and exercise, are pivotal in AFLD management. Emerging therapeutic strategies targeting key molecular pathways involved in AFLD, such as mitochondrial dysfunction, lipid peroxidation, and inflammation, show promising results in preclinical studies. Furthermore, advances in precision medicine offer new avenues for personalized treatment approaches based on individual genetic susceptibility and disease severity. However, several challenges remain, including the need for large-scale clinical trials to validate the efficacy and safety of novel therapeutics. In conclusion, a comprehensive understanding of the complex pathophysiology of AFLD and the development of targeted treatment strategies hold the potential to mitigate the escalating burden of liver disease worldwide.

Keywords: AFLD (Alcoholic fatty liver disease), Fibrosis, Steatohepatitis, Risk factors.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia