SOLID LIPID NANOPARTICLES AS ATTRACTIVE DRUG CARRIER: COMPOSITION, PREPARATION AND APPLICATION
Arathi T. P.*, Shripathy D. and A. R. Shabaraya
ABSTRACT
Solid lipid nanoparticle (SLN) introduced in 1991, have emerged as an alternative to traditional colloidal carriers like liposomes, polymeric nanoparticles, microparticles, and emulsions. SLNs show various distinctive features such as low toxicity, large surface area, prolonged drug release, targeted drug delivery, superior cellular uptake as compared to traditional colloidal carriers as well as capability to improve solubility and bioavailability of drugs. This paper gives an overview about the potential advantages and also the disadvantages of solid lipid nanoparticles, the excipients, classification of SLN, all the different methods involved in their production and biomedical application.
Keywords: solid lipid nanoparticle, colloidal carriers, targeted drug delivery.
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