EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

INVESTIGATING THE LINK BETWEEN SKIN CD103+ MEMORY CELLS AND THE SEVERITY OF PSORIASIS

Nora Harfouch*, Fouz Hassan, Mohamad Adel Ismaiel, Ali Daoud and Allam Harfoush

ABSTRACT

Background: Tissue-resident memory T cells (TRMs) represent a subpopulation of memory T cells garnering significant attention in contemporary psoriasis research. These cells exhibit the unique capacity to persist within psoriatic skin even during periods of disease remission. This persistence has led researchers to posit a pivotal role for TRMs in the cyclical recurrence of psoriasis. TRMs are hypothesized to contribute to the complex immunopathogenesis of the disease, thereby positioning them as a potential therapeutic target for novel treatment strategies. Materials and methods: a prospective observational study conducted at Tishreen University Hospital between December 2021 and December 2023, the severity of psoriasis was assessed using the Psoriasis Area and Severity Index (PASI). Skin biopsies were obtained from previously psoriatic lesions to evaluate the density of CD103+ cells within the epidermis and dermis using immunohistochemistry. Subsequently, correlations between CD103+ cell counts and PASI scores were analyzed. Results: Eight participants with healed psoriasis were enrolled in this study, with a median age of 44 years. The gender distribution was balanced, with 50% of participants being male. A significant correlation was observed between PASI scores and epidermal CD103+ cell counts. Conclusion: The extent of infiltration with CD103 cells in the epidermis of psoriasis is linked to the severity measured with PASI.

Keywords: Psoriasis – cd103 – memory cells – PASI – severity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia