EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

ASSOCIATION OF E-SELECTIN GENE POLYMORPHISMS IN EGYPTIANS WITH CORONARY ARTERY DISEASE

Heba Mosaad, Mohamad Motawea, Ahmed El Said and Ola El-Shimi*

ABSTRACT

Genetic polymorphisms of the E-selectin are associated with coronary artery disease. Objectives: We aimed to investigate the association between the A561C and G98T polymorphisms in E-selectin gene and coronary artery disease in Egyptian population. Subjects & methods: The study enrolled 251 individuals, classified into 2 groups: 152 coronary artery disease patients and 99 normal healthy individuals. A561C and G98T polymorphisms of E-selectin were analyzed by PCR-RFLP (Polymerase chain reaction - Restriction fragment length polymorphism) technique. Results: The frequency of C allele of the E selectin A561C polymorphism was higher in coronary artery disease patients than control group but with no statistical significant difference between the two studied groups (p=0.53). The frequency of T allele of G98T polymorphism of E-selectin was higher in coronary artery disease patients when compared to control group but with no statistical significant difference (P=0.36). Conclusion: A561C and G98T polymorphisms of E-selectin gene are not associated with the predisposition to coronary artery disease and appear to be protective in Egyptian population.

Keywords: E-selectin, polymorphism, PCR-RFLP, CAD, Egyptians.

[Full Text Article] [Download Certificate]