EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

STUDY THE POTENTIAL DRUG-DRUG INTERACTION THROUGH PRESCRIPTIONS ANALYSIS IN SOME SANA'A CITY HOSPITALS, YEMEN

Mohammed A. Alkhawlani, Ahmed M. Al-Ghani and Mahmoud Mahyoob Alburyhi*

ABSTRACT

Drug-drug interactions (DDIs) occur during the co-administration of medications. They are a common cause of adverse drug reactions (ADRs) and lead to increasing healthcare costs. Objective: To assessment of frequency, severity and mechanism of DDIs through prescriptions analysis in some Sana'a hospitals. Methods: The cross-sectional observation study was performed on some Government and private hospitals in Sana'a city from June 2022 to April 2023. Prescriptions with two or more drugs prescribed were selected for the study stratified by age, sex, and frequency of common interacting drugs. Drugs were analyzed for interactions by using the Medscape drug interaction checker. Potential drug-drug interactions (pDDIs) were classified based on the severity and mechanism of interactions. Results: A total of 1321 prescriptions were collected from various section of both Government and private hospitals, 398 prescriptions with one drug were excluded from study and 923 prescriptions analyzed, of which 299 prescriptions had 989 pDDIs. From these, 51.5% was female, and 48.5% male. The study findings showed that the prescriptions for Private hospital had the greatest number of drug interactions. Most of the pDDIs by mechanisms were pharmacokinetic drug interactions (52.8%) followed by pharmacodynamic (47.2%). The Department in the hospital I.C. U had the greatest number of drug interactions. A severity assessment showed that majority of the DDIs were moderate (58.6%) followed by Mild (24.2%) then Sever (16.4%). The study results showed that as the number of drugs increases in a prescription, the number of DDIs also increases. Conclusion: In our study, we found that most common pDDIs were more in prescriptions of private hospital in Sanaa, Pharmacokinetic in nature and of moderate severity. The number of pDDI increased with increase the number of drugs prescribed.

Keywords: Drug-Drug Interaction; Adverse Drug Reaction; Prescription; Sana'a city; Yemen.

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