( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Navpreet Kaur*, Nirmala, S.L Harikumar


ABSTRACT The buccal region offers an attractive route of administration for systemic drug delivery. Losartan is an angiotensin II receptor antagonist readily absorbed from the GIT, following oral administration. It has low bioavailability as it undergoes extensive first pass metabolism and low elimination half life. The present study was aimed at studying controlled release behavior of the drug using hydrophilic and hydrophobic polymers. The mucoadhesive polymers used in the formulation were ethylcellulose (hydrophobic), hydroxypropyl methyl cellulose and polyvinyl pyrrolidone (hydrophilic). These polymers were used to evaluate the effect of hydrophilic and hydrophobic polymers on the release pattern of the drug. Various mucoadhesive buccal films were prepared by employing EC alone, HPMC alone, PVP alone and in combination of all polymers in different ratios by solvent casting method using ethanol, and water as solvents, propylene glycol as plasticizer. The prepared mucoadhesive buccal films were evaluated for their physicochemical parameters such as weight uniformity, thickness uniformity, folding endurance, drug content, surface pH, swelling index, in vitro release studies, ex vivo mucoadhesion time, ex vivo permeation studies and stability studies. Patches exhibited controlled release for a period of 10 hrs. The mechanism of drug release was found to be Fickian diffusion and followed the zero-order kinetics. The mucoadhesive buccal patches of Ethylcellulose-Hyroxypropyl methyl cellulose in ratio of 1:4 (EH4) was concluded to be optimized. The optimized patches showed comparable swelling index, significantly higher mucoadhesive strength, higher in-vitro drug release, more mucoadhesion time and more cumulative percentage of drug permeated than mucoadhesive buccal patches of ethylcellulose-polyvinyl pyrrolidone in ratio of 1:4 (EP4). From the above results, it can be concluded that blends of hydrophobic and hydrophilic polymers is better than single polymer to obtain sustained drug release and can be used to formulate mucoadhesive buccal patches of losartan to bypass first pass metabolism and hence bioavailability of losartan.

Keywords: Losartan, mucoadhesive, buccal delivery, hydrophilic and hydrophobic polymers.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 October 2021 Issue has been Published, Kindly check it on


    OCTOBER Issue has been successfully launched on 1 October 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )