ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF BUSPIRONE HYDROCHLORIDE IN BULK AND ITS PHARMACEUTICAL FORMULATION BY UV SPECTROMETRY
Panikara Kalyani, Pusuluri Teja Sree, Vollala Teja, Gandham Bhavana, Chelpuri Praneetha, Gokarakonda Tejaswi and Srinivas Chinta*
ABSTRACT
Simple, accurate, rapid and sensitive method developed for the determination of buspirone hydrochloride in bulk drug and in its tablets by UV Spectroscopy. In mmethod, buspirone hydrochloride estimated at 244 nm using distilled water as a solvent. The linearity was observed in the concentration range of 2-12 μg/ml with correlation co efficient of 0.998. The result of analysis for the method was validated statistically and by recovery studies. Validation was performed according to ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The proposed method may be suitable for the analysis of Buspirone in tablet formulation for quality control purposes.
Keywords: UV Spectrphotometry, and Validation, Precision, Accuracy, LOQ, LOD, ICH guidelines, Buspirone Hydrochloride.
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