EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

COMPARISON OF ORAL ITRACONAZOLE WITH ORAL FLUCONAZOLE IN TREATMENT OF VULVOVAGINAL CANDIDIASIS

*Zahra Iftikhar, Shazia Sehgal and Ussama Maheen

ABSTRACT

Introduction: Vaginal candidiasis is a common disease in women during their lifetime, during pregnancy and oral contraceptives users. Although several antifungals are routinely used for treatment; however, vaginal candidiasis is a challenge for patients and gynecologists. Objectives: To compare the efficacy of oral itraconazole with oral fluconazole in treatment of patients of vulvovaginal candidiasis presenting to Outpatient Department of a tertiary care hospital. Study Design: Randomized controlled trial. Setting: Department of Obstetrics and Gynaecology, Unit-3, Jinnah Hospital, Lahore. Duration of Study With Dates: Study was carried out over a period of six months from 17-11-2017 to 16-05-2018. Subjects And Methods: A total of 148 patients (74 in each group) were enrolled in this study. Group-A received Oral itraconazole (200mg twice daily for one day) and group-B administered with Oral fluconazole (150mg single dose). Results: In group-A mean age of the patients was 23.2±4.2 and in group-B 21.7±2.8 years. Married patients were 25 (33.8%) in group-A and 13 (17.6%) in group-B and remaining were unmarried. Majority of the patients belonged to lower socioeconomic status in both groups. Mean duration of disease was 1.6±0.6 and 2.2±0.7 weeks in group-A and B, respectively. In group-A 20 patients (27%) and in group-B 5 (6.8%) were diabetic. 16 patients (21.6%) of group-A and 5 patients (6.8%) of group-B used IUCD. Efficacy was found to be in 66 patients (89.2%) of group-A and 53 patients (71.6%) from group-B. Stratification with regard to age, marital status, socioeconomic status, duration of disease, diabetes status and use of IUCD was also carried out. Conclusion: Itraconazole was found to be more effective in the treatment of vulvovaginal candidiasis compared to fluconazole, and might represent a better choice in treating the condition.

Keywords: Vulvo Vaginal Candidiasis, Oral Fluconazole, Oral Itraconazole.

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