FAST DISSOLVING TABLETS OF PHENYTOIN BY HOLE TECHNOLOGY

Nireeksha Shetty*, Krishnananda Kamath K., Mukesh Vishwakarma and A. R. Shabaraya

ABSTRACT

Research has been done to prepare Phenytoin fast dissolving tablets (FDT) by Hole technology. Once these fast-dissolving tablets contact with gastro enteric fluids, the fluid can enter the hole within the tablet and immediate disintegration of tablets takes place. Fast dissolving tablets of Phenytoin was designed with a view to provide a quick onset of action. Here fast dissolving tablets were prepared by direct compression by using super disintegrants such as Sodium Starch Glycolate and Croscarmellose Sodium. This quick disintegration of tablets is additionally influenced by the formation of space between granules. FDTs were subjected to numerous pre and post formulation parameters. From all the formulations F1, F2, F3 and F4, F3 was found to be best formulation. Evaluation parameters like hardness and friability indicates that the tablets were mechanically stable in all formulations. Its disintegration and dissolution rates were compared. At the end of 30 min formulation F3 released 98.38 % of drug and considered as best formulation. Phenytoin fast dissolving tablets prepared by whole technology using camphor as a sublimating agent and shows excellent drug release from the tablet.

Keywords: Fast Dissolving Tablets, Phenytoin, Sublimation, Hole Technology.