EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIOXIDANT THERAPIES TO OXIDATIVE STRESS RELATED NEUROTROPHINS INVOLVED IN ALZHEIMER’S DISEASE

Amit Chaudhary, Rashmi Tripathi, Yashasvi Jain and Satyavani Guttula*

ABSTRACT

Alzheimer Disease (AD) is the most common form of dementia affecting aging population. The pathogenetic process and clinical manifestation of the dementing disorders includes pathophysiological hallmarks (a) extracellular β-amyloid protein's (Aβ) senile plaques deposition (b) intracellular deposition of the microtubule associated protein tau as neurofibrillary tangles (NFTs). Neurotrophins play a vital role in adult neuron survival, maintenance, regeneration besides being required for the correct development of the nervous system. Two neurotrophic factor candidates involved in the progression of AD are NGF and BDNF. Both are affected early in the disease and is initiates a cascade of events. Studies show that antioxidant therapies is a promising therapeutic strategy which show success in pre-clinical studies. Therefore, this paper mainly focuses on the recent developments of commonly used antioxidant therapies for AD and provides indications for future potential antioxidant therapeutic strategies for neurodegenerative diseases. Here, docking of some antioxidants with neurotrophins (like BDNF and NGF) is done using Glide 6.2v. The glide energy calculated can easily predict the rank poses of the different ligands and binding affinity of ten compounds. Theaflavin, Catechin, Luteolin, Kaemferol, Gallic acid, Myricetin, Eriodictyol, Uric acid, Ascorbic and Isorhamnetin acid are top ten highly ranked compounds that produced the best rank poses with three different proteins (1NT3, 1BND, 1B8M). The docking result reveals that these compounds can reduce the oxidative stress, play an important role in reducing the risk or postponing the clinical onset of progressive-dementia and further may enhance the efficacy of antioxidant based treatment strategy.

Keywords: Alzheimer Disease, ?-amyloid protein's, neurofibrillary tangles, Antioxidant, Neurotrophins BDNF, NGF, Oxidative stress


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )