NOVEL SYNTHESIS AND EVALUATION OF ANTIMICROBEAL ACTIVITY OF SUBSTITUTED N-(PYRIDIN-4-YL METHYLENE)-2-AMINO BENZOTHIAZOLE
V. K. Jadhav, A. S. Mathwale and A. B. Chidrawar
ABSTRACT
The synthesis of N-(pyridin-4-ylmethylene)-2-amino benzothiazole (3) by reaction of 2-amino benzenethiol (1) and isonicotinaldehyde (2) stirring in presence of methyl alcohol as a solvent. This reaction mixture is kept for overnight, the crystals of N-(pyridin-4-ylmethylene)-2-amino benzothiazole (3) obtained. Filtered and dried. The synthesis of 5-nitro-N-(pyridin-4-ylmethylene)-2-amino benzothiazole (5) by reaction of 5-nitro-2-amino benzothiazole (4) and isonicotinaldehyde (2) stirring in presence of methyl alcohol as a solvent. This reaction mixture is kept for overnight, the crystals of 5-nitro-N-(pyridin-4-ylmethylene)-2-amino benzothiazole (5) obtained. Filtered and dried. The Purity of compound was checked by TLC. The compound observed on TLC as single spot in benzene. The structures for the synthesized compounds are assigned on the basis of IR, 1HNMR and Mass spectral studies.
Keywords: 2-amino benzenethiazole, 5-nitro-2-amino benzenethiazole, isonicotinaldehyde, methyl alcohol, N-(pyridin-4-yl methylene)-2-amino benzothiazole.
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