ACUTE TOXICITY AND LETHAL DOSE INVESTIGATION OF DIBENZYLIDENE DERIVATIVES PROFILED ALONG AGE VARIATIONS IN MICE

Erigbali P.P*., Kemelayefa OJ., Joffa PPK., Kiridi E.G. and Pughikumo D.T

ABSTRACT

In line with search for viable alternative medications with minimized adverse side effects, five derivatives of dibenzylidene synthesized in the pharmaceutical and Medicinal chemistry laboratory of Niger Delta University and labeled as D1 to D5 were investigated in a preliminary study. Acute toxicity and lethal dose studies in accordance with the method of Lorke were done amongst groups of mice with known age range. Following administration of the derivatives, a twenty-four hour observation period ensued for examining behavioural and physiology related toxicities. Results present some derivatives of dibenzylidene to have inflicted severe toxicity signs and mortality where others had mild toxicity signs and without mortality. The death recorded was within age group one (1) week which statistically was (?)

Keywords: Toxicity, Dibenzylidine, LD50, Age, Derivatives, Mortality.