TO STUDY PHARMACOLOGICAL ACTIVITIES OF LANTANA MONTEVIDENSIS

Prof. Harshada Shewale, *Pundalik Chandgude, Vaishnav Chavan, Pooja Choudhary, Preksha Bongirwar and Dhanshri Chaudhari

ABSTRACT

The pharmacological actions of Lantana montevidensis extracts were investigated across various domains, revealing promising therapeutic potential. Antifungal activity was observed in the essential oil extracted from L. montevidensis leaves, particularly when combined with fluconazole, enhancing its efficacy against Candida strains. Modulatory effects were demonstrated through the reduction of minimum inhibitory concentrations (MICs) of aminoglycoside antibiotics, suggesting a role in combating antibiotic resistance. Significant antioxidant activity was observed in both aqueous and ethanolic extracts, with the aqueous extract exhibiting stronger potency than ethanolic extract and ascorbic acid in scavenging DPPH free radicals. Cytotoxic effects on human leukocytes and erythrocyte membranes were noted, attributed to various compounds including gallic acid, catechin, chlorogenic acid, and quercetin. Furthermore, ethanolic extracts from L. montevidensis leaves and roots displayed notable antibacterial activity against multi-resistant bacterial strains, indicating potential therapeutic applications. Evaluation against L. donovani parasites and T. brucei brucei trypomastigote forms revealed promising antiproliferative activity, suggesting a role in combating parasitic infections. Overall, the findings highlight the diverse pharmacological potential of L. montevidensis extracts, warranting further investigation for therapeutic development.

Keywords: Antifungal activity, Antibacterial, Antioxidant, Antiprotozoal, Modulatory, Cytotoxic