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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Kouame Yao Yves*, Okpekon Aboua Timothée, Yapi Houphouët Felix, Gbassi Gildas, Assi Yapo Jean, Kouakou Yeboue Koffi François


Xylopia villosa is a plant whose barks stems and ground seeds were used in treatment of cold, headaches, ulcers and boils. This study aims to determine secondary metabolites and acute toxicity parameters of Xylopia villosa barks stems of aqueous and hydroethanolic crude extracts in female Wistar rats. The phytochemical screening performed, revealed that both extracts contain alkaloids, polyphenols, leucoanthocyanins, saponins, flavonoids, sterols and polyterpenes. However there are no quinones and tannins (catechin and gallic) in these extracts. With regard to parameters, we obtained 2000 mg / kg body weight (bw), 281.83 mg / kg bw and 275 mg / kg bw indicating successively the lethal dose 100 (LD100), lethal dose 50 (LD50) and tolerated maximum dose with aqueous extract. The hydroethanolic extract of Xylopia villosa barks stems administered by intraperitoneal route at dose 5000 mg/kg of bw caused no morbidity and lethality. This result indicated the LD50 of hydroethanolic extract is higher than 5000 mg / kg bw. According to Global Harmonized Classification System (SCGH), hydroethanolic extract of this plant is hardly toxic.

Keywords: Phytochemical screening, Xylopia villosa, Secondary metabolites, Acute toxicity, lethal dose, Côte d’Ivoire.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database