EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

BENZAMIDE DERIVATIVES: A MULTIFACETED APPROACH TO TARGETING ALZHEIMER'S DISEASE PATHOLOGY

Mohammed Sahad P.*, Amirashirin K. T., Amna Hameed Thayyil, Mridhul Mohan P. and E. Tamil Jothi

ABSTRACT

Alzheimer's disease (AD) remains a prominent neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and behavioral changes. Pathologically, AD is marked by the presence of beta-amyloid plaques and neurofibrillary tangles in the brain, leading to synaptic and neuronal loss. Various hypotheses have been proposed to elucidate the underlying mechanisms of AD, including the Tau Hypothesis, Cholinergic Hypothesis, Amyloid Cascade Hypothesis, Mitochondrial Cascade Hypothesis, and Inflammation Hypothesis. These hypotheses provide insights into different aspects of AD pathology, ranging from protein aggregation to neurotransmitter dysregulation and inflammatory processes. In the search for effective treatments, numerous drug targets have been identified, including Aβ and Tau proteins, enzymes involved in Aβ production (BACE-1, γ-secretase), cholinergic pathways, serotonin receptors, and neuro-inflammatory pathways. Despite significant research efforts, developing effective therapies for AD remains challenging. Benzamide derivatives have emerged as potential candidates for AD treatment, with studies exploring their role as cholinesterase inhibitors, modulators of Aβ biosynthesis enzymes, inhibitors of tau aggregation, and antioxidants. These compounds offer a multifaceted approach to addressing different aspects of AD pathology, including enhancing cholinergic neurotransmission, reducing Aβ production, and mitigating oxidative stress and neuroinflammation. In conclusion, understanding the complex pathophysiology of AD and exploring novel therapeutic strategies, such as benzamide derivatives, holds promise for the development of effective treatments to alleviate the burden of this devastating disease. Further research is needed to fully elucidate the efficacy and safety of these compounds in clinical settings.

Keywords: Alzheimer's disease (AD), Amyloid-beta peptide (A?), Tau Protein, Benzamide derivatives, Drug Targeting.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia