EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

RP HPLC METHOD DEVELOPMENT & VALIDATION OF MONTELUKAST & FEXOFENADINE IN PHARMACEUTICAL DOSAGE FORM

Swapnil B. Deshmukh*, Jayshri A. Patil, Umesh T. Jadhao and Sandip T. Thoke

ABSTRACT

A simple, accurate and precise RP-HPLC method was developed and validated for determination of Montelukast Sodium (MONT) and Fexofenadine hydrochloride (FEXO) in pharmaceutical dosage form. The chromatographic separation was achieved on (Cosmosil) C18 column (4.6mm x 250mm) as stationary phase with a mobile phase comprising of Acetonitrile: Water(0.1% with OPA) 70:30 adjust pH 3 at a flow rate of 1.0 mL/min, column at Ambient temperature and UV detection at 241 nm. The retention time of Montelukast Sodium and Fexofenadine hydrochloride were 5.3666 min and 6.8333 min respectively. The linearity were found to be in the range of 1-5 μg/mL and 12-60μg/ml for Montelukast Sodium and Fexofenadine hydrochloride with correlation coefficient greater than 0.999. The precision of the method was demonstrated with % RSD while the % recovery was found in between 99.69 -100.17%. The proposed methods were validated as per ICH guidelines and successfully applied for the determination of investigated drugs in tablets.

Keywords: Montelukast Sodium, Fexofenadine hydrochloride, RP-HPLC, validation.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia