EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

ENVIRONMENTAL FRIENDLY SYNTHESIS AND CHARACTERIZATION OF BENZOPYRANS USING HEXAFERRITE AS GREEN CATALYST: A SIGNIFICANT STEP TOWARDS SUSTAINABLE CHEMISTRY

Chandrashekhar A. Ladole*

ABSTRACT

This research work aims to explore the synthesis, structural characterization, and biological evaluation of
benzopyran derivatives utilizing ethyl acetoacetate, β-naphthol, and aromatic aldehydes with ferrite as catalystassisted
methodologies. Benzopyrans are of particular interest due to their properties useful in pharmacological and
biological activities, as well as their synthetic versatility. The study focuses on enhancing sustainability through
efficient synthetic routes. Various nanocatalysts, including organic and inorganic, were investigated to facilitate the
formation of benzopyran derivatives. The heterogeneous hexaferrite catalyst is an attractive option for
multicomponent reactions due to its ease of preparation, cost-effectiveness, and insolubility in most organic
solvents. The protocol offers several advantages, including control over reaction conditions, high yields, easy
workup, reproducibility of catalytic activity, compatibility with substrates, and enhanced overall efficiency of the
reaction. Additionally, it helps minimize waste generation, reduce energy consumption, and utilize environmentally
benign catalysts efficiently. The synthesized compounds were confirmed using FT-IR, 1H NMR spectroscopic data,
and melting points, which were compared with reported values. During the work-up procedure, the catalyst can be
easily recovered and recycled, retaining its activity for up to four cycles.

Keywords: Benzopyrans, multicomponent reaction, heterogeneous hexaferrite catalyst.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia