EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

THERAPEUTIC POTENTIAL OF BETA-CARYOPHYLLENE (BCP) IN POLYCYSTIC OVARIAN SYNDROME (PCOS): INSIGHTS FROM RAT MODEL STUDIES

Anushiya V.*, Balamurugan S. and Marihrishnaa K.

ABSTRACT

Beta-caryophyllene (BCP) was investigated for its potential therapeutic benefits on polycystic ovarian syndrome (PCOS), a common endocrine disorder in women. PCOS is characterized by metabolic disorders, insulin resistance, anovulation, and hyperandrogenism. Its aromatic properties make BCP an important component of many products, despite its structural similarities to cannabinoids. In this study, BCP was studied for its impact on ovarian follicle quantity and quality in PCOS rats and for its impact on weight and ovarian size in these rats. A significant difference was found between the BCP-treated control group and the estradiol valerate-treated control group in terms of LH and FSH levels. A BCP treatment also elevates estradiol and progesterone levels, decreases testosterone, restores antioxidant enzyme activity, and reduces oxidative stress in ovarian tissue. Further, BCP treatment reverses the histomorphometric changes in ovarian structure seen in PCOS rats and increases the number of ovarian follicles. According to these studies, BCP might be effective in treating metabolic and reproductive problems related to PCOS.

Keywords: Polycystic ovary syndrome (PCOS), Beta-caryophyllene (BCP), Reproductive disorders, Ovarian follicles, Antioxidant therapy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia