A COMPREHENSIVE REVIEW ON LYOPHILIZATION (FREEZE-DRYING) TECHNIQUE
Selvi G.*, Priya Darshini R., Anushiya M. and Deepakumari V.
ABSTRACT
In the realm of pharmaceutical formulation, lyophilization stands out as a crucial technique offering distinct advantages over conventional methods. Its ability to safely dry heat-sensitive vaccines, antibiotics, and protein-based products has rendered it indispensable in modern medicine. Particularly in the context of lyophilized powder formulations, the reconstituted product can be swiftly utilized post-lyophilization, facilitating ease of administration and storage. As the demand for injectable biopharmaceuticals continues to surge, lyophilized products have assumed heightened significance in the pharmaceutical landscape. The evolution and proliferation of lyophilization techniques underscore its escalating importance in 21st-century pharmaceutical endeavors. While historically perceived as an expensive process, the transformative impact of lyophilization on drug stability and efficacy cannot be overstated. In earlier times, it is primarily viewed as a means of drying; however, its role has since expanded significantly, with pharmaceutical formulations now heavily reliant on this method. This review places a spotlight on recent advancements within the field, shedding light on potential avenues for future exploration and innovation. By delving into the core principles, procedural nuances, formulation considerations, and overarching significance of lyophilization, this discourse seeks to provide a holistic perspective on this indispensable pharmaceutical process.
Keywords: Freeze drying, Vacuum, Vapour Pressure, Dryer.
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