An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Abin Joy*, Chaitra N. and Mukund Handral


The main aim of the study was to carry out and investigate the Antiosteoporotic activity of ethanolic extract of Cardiospermum halicacabum (EECH) in ovariectomy (OVX) induced osteoporotic rats. All the rats were randomly divided into 5 groups (n=6 each). Group I (Sham operated) received vehicle, p.o., Group II OVX control (vehicle, p.o), Group III was OVX + standard Raloxifene (5.4 mg/kg, p.o) and Group IV& V received OVX + 300 & 600 mg/kg, p.o. of EECH respectively for 90 days. The studies revealed that EECH showed a dose dependent improvement in serum biochemical markers, which were significantly (P<0.0001) higher, whereas the urinary excretion profile was reduced in extract treated when compared to OVX control group. Similarly, in biomechanical parameters also EECH showed a significant change in body weight, bone mechanical strength (P<0.01), ash content (P<0.0001) and BMD (P<0.05) when compared with OVX control rats. Further, histopathological sections studied from the femur bone supported protective effect of EECH, as it restored the normal bone architecture by mineralisation with calcified cartilaginous deposit. All these results significantly indicate a remarkable antiosteoporotic activity of EECH. However, further studies are required to explore the exact mechanism of EECH on improving bone mass and qualities as well as its long term effect on maintenance of bone mass.

Keywords: Cardiospermum halicacabum, Ovariectomy (OVX), Osteoporosis, Biochemical markers, Ash mineral content and BMD.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing