FORMULATION AND EVALUATION OF HERBAL NASAL DROPS FOR MIGRAINE

Sagar M.*, Mamatha A., Yashwanth S., Shrikrishna M. Naik and Sharath T. P.

ABSTRACT

A migraine headache is a complex Neurological disorder, where a person experiences a throbbing sensation in the head on the unilateral side. “World Health Organization has grades migraine as 6th among disability causing diseases”. Getting rid of it perpetually can be challenging with conventional medicines. Synthetic drugs for Migraine are often associated with side effects, due to which patients are hesitant to take these medications and prefer herbal remedies. A specific protein called calcitonin gene-related peptide (CGRP) associated with inflammation and pain is involved in migraine. Small c-fibers on the trigeminal nerve, when triggered, release CGRP protein and causes Migraine. Many herbs can block pain signals to the brain by inactivating the chemical messenger CGRP. Nasal Drops are can be efficacious in treatment of Migraine. A drug that is delivered through the nasal mucosa is rapidly absorbed into the bloodstream because of a thin mucosa and a rich blood supply. Moreover, a nasally route is an alternative to people with migraine experiencing nausea and/or vomiting. Many herbs expected to be useful in treatment of migraine like Ginger, Butterbur, Caffiene, Black jeera, Turmeric, Ashwaganda and Menthol has anti-inflammatory, abortive and prophylactic activity for migraine are chosen. Thus, in this study a poly herbal nasal drops is formulated and further evaluated.

Keywords: Migraine, CGRP, Nasal drug delivery system, Herbal, formulation and evaluation.