( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Erigbali P. P.,* Joffa P. P. K., Kiridi E. G., Pughikumo D. T., Ekeocha J. and Bisong J.


The challenges associated with medications for the treatment of neurodegenerative disorders such as Alzheimer’s disease is enormous, so that the curiosity and search for alternative ameliorative therapy is continuing to garner attention and interest in research climes. Thus, in this study the objective was to investigate the neurobehavioural effects of a combination therapy (of ginseng + vitamin E), and possible remedy it may proffer in other to reverse stress, then restore and /or improve cognitive function in an experimental Swiss mice model. Mice were induced with stress by two models (biological and chemical) under which conditions they were allowed treatment with combination of ginseng + vitamin E, as well as treatment with vitamin E alone to compare with a control group that was not treated. At the end of the study duration of the experiment design, all the groups of mice were taken for Neurobehaviour tests, using Morris water maze and T-maze test which are standard protocol for investigating learning and memory behaviour in rodents. Relevant parameters that depict learning, memory / cognitive function were measured. The results showed that in the non-stressed mice treated with vit E + ginseng, the retention quadrant duration (to depict memory) increased significantly (P<0.01) than control. In the same vein, the stressed mice had mean retention quadrant duration which was increased significantly (p<0.01) for both mice groups that were treated (i.e. vit E + ginseng and vitamin E) and the mean annulus reversal crossings were increased significantly (p<0.001) in vit E + ginseng and vitamin E compared to control. Meanwhile, in comparing the efficacy between the treatment with vitamin E alone (single therapy) and vitamin E + ginseng (combination therapy), the observation was increased in single therapy than the combination therapy for biologically stressed mice, while it was increased in combined therapy than single therapy for chemically stressed mice, although not significant statistically. In conclusion, it is conceivable that a combination of ginseng and vitamin E (combination therapy) in scientifically determined proportions and dosage could be more beneficial in impacting a reversal in the process of memory impairment in experimental mice model.

Keywords: Ginseng, Vitamin E, biological Stress, chemical stress, Learning, memory.

[Full Text Article] [Download Certificate]


  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 June 2024 Issue has been Published, Kindly check it on


    JUNE 2024 issue has been successfully launched on JUNE 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.


  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia