ORODISPERSIBLE FILMS - A REVIEW
Nireeksha Shetty*, Krishnananda Kamath K., Shripathy D. and A. R. Shabaraya
ABSTRACT
Oral application is the most acceptable, non-invasive, and widely used route of drug administration. Various dosage forms for oral drug delivery: syrups, suspensions, drops, tablets, capsules or chewing gums are available. However, each of them raises some problems related to their administration and dosing. Moreover, several groups of patients have considerable swallowing difficulties, dysphagia, or fear of choking, which hamper their therapy as well as complicate patient compliance and adherence. To eliminate difficulties exhibited by traditional solid oral dosage forms and meet the expectations of today’s patients, more and more formulations appear as orodispersible drug delivery systems, orodispersible films (ODFs). Orodispersible films (ODFs) are novel drug delivery systems for the oral delivery of the drugs in an ultra-thin film form prepared using hydrophilic polymers that rapidly dissolves on the top or the floor of the tongue or buccal cavity. Use of orodispersible formulations avoids the risk of choking, which may occur in the case of conventional tablets or capsules. It is also suitable for patients who are not willing to cooperate or face the difficulties associated with complete dosage intake, such as patients with depression, schizophrenia, dementia, and other neurodegenerative diseases. ODFs are at the cutting edge of drug technology as they offer a good alternative for rapid drug delivery.
Keywords: Orodispersible films, formulation, mechanical properties, packaging.
[Full Text Article]
[Download Certificate]