THE HEMOSTATIC ACTIVITY OF GAMBHARI PHALA (GMELINA ARBOREA ROXB.) – INVITRO STUDY

Dr. Devika M. L.* and Dr. Bharati Muddannavar

ABSTRACT

Medicinal plants with a variety of phytochemical ingredients remain a potential source for new drug discovery. The use of medicinal herbs in a wide range of diseases and symptoms, such as bleeding is prevalent in traditional and ethno medicine worldwide. There are only few drugs in Ayurveda having hemostatic activity. Gambhari is one among the potent and widely used drug in Ayurveda with promising hemostatic effect. It’s one among the Dashamoola. Gambhari phala is mentioned as Agrya for raktapitta and Raktasangrahi by Acharya Charaka. The drug, Gambhari phala selected have kashaya madhura rasa, sheeta veerya, and madhura vipaka and pitta hara karma is assessed to have hemostatic activity in their respective aqueous and alcohol extracts. Aqueous and alcohol extracts of Gambhari phala prepared by Soxhlet extraction and invitro study for screening hemostatic activity was carried out by Lee white method. The aqueous and alcohol extracts of Gambhari phala were subjected to analytical evaluation. Invitro study revealed the presence of hemostatic activity. Presence of tannins, saponins, flavonoids, alkaloids, calcium ions are responsible for the hemostatic activity of aqueous and alcohol extracts of Gambhari phala.

Keywords: Gambhari phala, Hemostatic activity, Aqueous and alcohol extracts, Ayurveda, In vitro study.