ANTIDYSLIPIDEMIC ACTIVITY OF SOME MEDICINAL PLANTS FROM KARAWANG, WEST JAVA, INDONESIA: A REVIEW

Dissa Ayu Putri Andini, Dinar Salma Putri Utami, Ira Puspawati, Abielza Yugha Geralda, Ismi Puji Apriani, Delika Syalomita, Intan Nurcahyani, Risti Septanti, Reza Ardiansyah, Frisa Adelia Putri, Rendi Haryadi, Muhammad Gilang, Sri Marita, Muhamad Rizki and Maulana Yusuf Alkandahri*

ABSTRACT

Hyperlipidemia is a secondary metabolic dysregulation related to increased levels of triglycerides, cholesterol, and LDL in the serum, which is a major risk factor for premature cardiovascular disease such as arthrosclerosis, hypertension, coronary heart disease, etc. Increased plasma lipid levels, especially total cholesterol, triglycerides, and LDL, along with decreased HDL, are known to cause hyperlipidemia, which is the reason for the initiation and progression of atherosclerosis. Currently, researchers are searching for natural ingredients that have been empirically proven to possess antidyslipidemia effects, in order to identify new antidyslipidemia compound candidates. This is done to replace antidyslipidemia drugs, which currently have many side effects. Several medicinal plants native to Karawang, Indonesia, including Curcuma longa, Aloe vera, Andrographis paniculata, Guazuma ulmifolia, Phaleria macrocarpa, Morinda citrifolia, and Moringa oleifera, have been scientifically proven to have antidyslipidemia activity with different mechanisms. Therefore, this review article discusses the potential of several medicinal plants native to Karawang, Indonesia, which have antidyslipidemia effects.

Keywords: Antidyslipidemia, Medicinal plants, Curcuma longa, Aloe vera, Andrographis paniculata, Guazuma ulmifolia, Phaleria macrocarpa, Morinda citrifolia, Moringa oleifera.