EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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 ISSN 2394-3211

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Abstract

ONSET AND DURATION OF ACTION OF EPIDURAL BUPIVACAINE AND DEXAMETHASONE IN PATIENTS UNDERGOING BILATERAL INGUINAL HERNIORRHAPHY

Afolayan Jide Michael*, Olajumoke T. O. and Olaogun Julius

ABSTRACT

Objective: To evaluate the onset and action of epidural bupivacaine with or without dexamethasone in patients
undergoing bilateral herniorraphy. Methods: A prospective study of epidural bupivacaine with or without
dexamethasone in patients with bilateral inguinal herniorraphy from January 2015 to December 2020 was carried
out. A total of forty-eight patients were enrolled in this double-blind study. Forty-eight patients were randomized
into group BD (N=24) and received 20ml of epidural bupivacaine plus 3ml (12mg) of dexamethasone or group BN
(N=24) and received 20 ml of epidural bupivacaine plus 3ml of normal saline. The onset of sensory block, mean
arterial blood pressure, duration of action and incidence of complications were recorded. Results: Effective
intraoperative sensory block was achieved in all the patients in the two groups. The onset of epidural anesthesia
was significantly more rapid in the epidural group with dexamethasone than in the epidural group without
dexamethasone (P < 0.001). Duration of analgesia was markedly prolonged in the group with dexamethasone
compared to control group (P < 0.001). One patient (4.2%) in the control group had bradycardia in the immediate
post operative period (P = 0.030). Two patients in the dexamethasone group had bradycardia. None of the patients
had vomiting in the two groups. Conclusions: This study showed that addition of 12mg dexamethasone to epidural
bupivacaine is safe, significantly makes onset of action to be more rapid and prolongs the duration of postoperative
analgesia.

Keywords: Anaesthesia, analgesia, epidural, bupivacaine, dexamethasone.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia