EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

IN-VITRO STUDY OF THE ANTIBACTERIAL PROPERTY FROM THE HYDROETHANOLIC EXTRACT OF SPERMACOCE OCYMOIDES BURM (RUBIACEAE) PLANT ON ISOLATES OF MICROBIAL STRAINS RESPONSIBLE FOR IMPETIGO IN INFANTS

Theophile Mistral Mpaba Minkat*, Anne-Cécile Zoung-Kanyi Bissek, Marcellin Ndoe Guiaro*, Ericson Djeutassong Segning, Georges Cédric Mouncharou, Grace Nkoro, Joseph Ngoupayo and Hortense Gonsu

ABSTRACT

The pursuit of safe and effective therapeutic alternatives for treating impetigo in infants remains a persistent focus in pharmaceutical research. This study explores the in-vitro antibacterial activity of Spermacoce ocymoides Burm (Rubiaceae) against microbial strains associated with infantile impetigo. The methodology encompassed phytochemical screening to identify secondary metabolites, solid medium diffusion sensitivity tests, and determination of inhibition parameters through macro dilution in a liquid medium, along with subculture on solid agar. Oxacillin served as the reference antibiotic. Phytochemical screening revealed the presence of phenolic compounds (flavonoids, coumarins, tannins, and phlobatannins), sterols, anthocyanins, saponins, and terpenoids, while alkaloids were absent. Staphylococcus aureus was the sole identified pathogen in our isolates. Antibacterial assays demonstrated the efficacy of our extract against Staphylococcus aureus. Gradual concentration sensitivity assays at 500 mg/mL, 250 mg/mL, 125 mg/mL, and 62.5 mg/mL produced average inhibition zone diameters of 15 ± 0.71 mm, 7 ± 0.71 mm, 4 ± 0.71 mm, and 3 ± 0.71 mm, respectively. These values were lower than the 20 mm diameter of oxacillin at 5 μg/mL. Inhibition parameter determination yielded a Minimum Inhibitory Concentration (MIC) of 1.95 mg/mL and a Minimum Bactericidal Concentration (MBC) of 3.9 mg/mL, with an MBC/MIC ratio of 2, affirming the bactericidal effect of Spermacoce ocymoides Burm on Staphylococcus aureus isolates from impetigo pustules in infants. This research highlights the potential of Spermacoce ocymoides Burm as a promising antibacterial agent for impetigo treatment, laying the groundwork for further exploration and pharmaceutical development.

Keywords: Spermacoce ocymoides, Infant, Impetigo, Staphylococcus aureus.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia