EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECTIVE ALLEVIATION OF METHOTREXATE INDUCED HEPATOTOXICITY BY MURRAYA KOENIGII LEAF EXTRACTS

Highland H. N.*, Kanwar R., Engineer A. and Desai K. R.

ABSTRACT

Drug induced hepatotoxicity is a distressing cause of liver insult, since the liver is the prime site of metabolism and biotransformation. Hence the present investigation was aimed at evaluating the ameliorative action of potent herbal extracts of Murraya koenigii to counteract the drug induced liver injury. These extracts, aqueous and hydro-alcoholic are a rich source of bioactive phytochemicals known for its anti-inflammatory, antioxidant and immunomodulatory activity. Male albino mice weighing 35-40 gm were treated with Murraya koenigii (250mg/kg body weight) extracts against Methotrexate induced toxic model for 15 days. The body weight was insignificantly elevated following methotrexate dosing, however this change was reversed by administration of the Murraya koenigii extract. The decline in liver weight was evidence of the inhibitory effect of Methotrexate on liver biosynthetic activity. Although the extracts were found to restore the fall in liver weight, complete recovery in this gravimetric parameter was not observed. Biochemical analysis for key liver markers revealed a significant elevation in activity of liver transaminases, indicative of hepatic inflammation. Oral administration of both extracts could effectively curb the rise in ALT and AST, where the hydroalcoholic extract appeared to be more potent. In addition, the significant decline observed in the activity of enzymes involved in oxidative and energy metabolisms, was also efficiently ameliorated by M. koenigii extract treatment. Further metabolic insult due to Methotrexate dosing resulted in a significant fall in protein and cholesterol levels, reflecting inhibition of metabolic turnover. Both extracts were able to bring about a significant recovery in these metabolite levels, possibly expediting liver repair. Thus, the extracts being a rich source of antioxidants could lead to recovery, mitigating the induced toxic injury of Methotrexate, possibly by effectively scavenging the free radicals generated. It is also known that Murraya koenigii phytochemicals manifest anti- inflammatory effects by suppression of inflammatory inducers. Thus owing to the rampant, unsupervised use of medications, simultaneous administration of Murraya koenigii leaf extracts could provide the much required hepatoprotection to alleviate liver damage.

Keywords: Methotrexate, Liver, Mice, Murraya koenigii.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 May 2020 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR MAY ISSUE PUBLISHED

    MAY 2020 Issue has been successfully launched on 1 May 2020.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing