TRANSFERSOMES: NOVEL APPROACH FOR TRANSDERMAL DELIVERY
Sakshi Sharma and Dr. Ujjwal Nautiyal*
Transdermal drug delivery appears to be the most vital drug delivery
system because of its merit over conventional systems. Various
strategies can be used to augment the transdermal delivery which
includes iontophoresis, electrophoresis, sonophoresis, chemical
permeation enhancers, microneedles, and vesicular system (liposomes,
niosomes, elastic liposomes such as ethosomes and transfersomes).The
transfersomal system was much more efficient among all these strategies. These can deform
and pass through narrow constriction (from 5 to 10 times less than their own diameter)
without measurable loss. The system can be characterized by in vitro for vesicle shape and
size, entrapment efficiency, degree of deformability, number of vesicles per cubic mm.The
deformability characteristic of transfersomes give better permeation of drugs.
Keywords: includes iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system.
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