FORMULATION AND EVALUATION OF ANTIBACTERIAL ORODISPERSIBLE TABLETS OF ARTEMISIA ARBORESCENE EXTRACT HERBAL PRODUCT
Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany
Artemisia arborescence plant widely distributed in Yemen, traditionally used to treat dermatitis, allergic reactions, itchiness Lymphatic drainage, venous congestions asthma, hay fever, asthmatic bronchitis. The essential oil of this plant was traditionally used as an insect repellant, as flavorings and for fragrances. Inhalation of the oil is used to dilate and stimulate the bronchi, blood vessels of the heart and to stimulate the kidneys. The oil is for inhalation only. Artemisia arborescence has been used traditionally as an anti-inflammatory remedy. The essential oil of Artemisia arborescence has been reported to have antibacterial and antifungal activities as well as antiviral activity against HSV-1 and HSV-2. Artemisia arborescence essential oil also exhibited antifungal activity against Cladosporium cucumerinum. The cytotoxic activity of Artemisia arborescence can be attributed to the presence of α-bisabolol and palmitic acid. The extract has high the antibacterial and antiviral activity. Artemisia arborescence is commonly used in traditional medicine for a wide range of ailments including gastritis, gastric ulcer and food poisoning. Antibacterial activity of ethanol extract of Artemisia arborescence was evaluated at the dose of 250mg/kg and showed a significant activity. Artemisia arborescence was formulated as Orodispersible tablets ODTs and evaluate for organoleptic properties of ethanol extract of Artemisia arborescence. The results show that the extract was sparingly soluble, excellent flowability of extract powder, the best formulation of Orodispersible tablets, ODTs is F4 the release rate was 95.51% after 5min and disintegration time within 4min.
Keywords: Artemisia arborescence, Extract, Orodispersible tablets, ODTs, Herbal Products.
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