SUSTAINED DRUG DELIVERY SYSTEM – A REVIEW
Sagar S. Dalvi*, Dr. Santosh B. Dighe and Dr. Sanjay B. Bhawar
Modified release drug delivery systems are those that release a drug over a long period of time. Israel Lipowski's 1938 patent for drug delivery dosage forms was a precursor to sustained release. The benefits of sustained release are to prolong the effects of a drug and to reduce the need for repeated dosing. Additionally, these candidates are unsuitable for SRDDS. Plasma concentration response relationship: In most situations, plasma drug concentration rather than dose is more essential for pharmacological activity. However, medicines with pharmacological activity unrelated to plasma concentrations are poor candidates for oral SR drug delivery systems. Concentration dependency on transfer of drug: Such drugs are poor candidates for oral SR delivery methods if the drug has been transferred from one compartment to another using a zero order kinetic process. It should be kinetically first order.
Keywords: Sustained Release, Polymers, Matrix, Drug Delivery.
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