STUDY ON OUTCOME OF DIGOXIN USE IN HEART FAILURE PATIENTS

Mohamed Shakir, Farhan Rafeeque K. V., Mohammed Anaf V., Mohammed Usamahusnain, Dr. Jijo Joji*, Dr. Hanumanthachar Joshi K.

ABSTRACT

Aim and Objective: To compare the effectiveness and safety of the treatment with digoxin (exposed) and without digoxin (Unexposed) in heart failure patients. Materials and Methods: A prospective comparative study was carried out in Sri Jayadeva Institute of Cardiovascular Sciences and Research, Mysuru, Karnataka. Data were analyzed using SPSS, Excel and compared between group which had digoxin therapy and which do not have digoxin therapy for heart failure. Result: The study involved 200 patients, with 55.5% male and 44.5% female. In the exposed group (75 patients), the mean ejection fraction was 38.5, and in the unexposed group (125 patients), it was 40.4. Heart rate means were similar between the exposed (87.72) and unexposed (87.48) groups. Hospital stays were comparable, with a mean of 5.20 days in both groups. Sodium levels were slightly lower in the exposed group, while potassium levels were similar. Urea and creatinine levels also showed little variation between groups. Adverse drug reactions occurred in 32 patients from the unexposed group and 46 from the exposed group, with different severity levels. Conclusion: There is no difference between effectiveness in the exposed group and unexposed group, but the safety is more in unexposed group.

Keywords: Digoxin, Heart failure, Toxicity.