A STUDY OF DRUG UTILISATION PATTERN AND MEDICATION ADHERENCE OF ANTI EPILEPTIC DRUGS IN TERTIARY CARE HOSPITAL
Hari Sankar, Haritha S. C., Heena Kouser, Helan S.*, Chaitanya Kumar T. and Janaki Torvi
Objectives: The primary objective was to study the drug utlisation pattern of anti epileptic drugs in a tertiary care hospital. The secondary objectives of the study were to identify the common classes of drugs prescribed and indications for the therapy, to assess and identify the potential drug interactions, to identify the extent of polytherpy with antiepiletic drugd in enrolled patients, to study the medication adherence behavior among enrolled patients. Materials & Methods: A Prospective Observational study of 6 months duration from March 2022 to August 2022 was carried out after Institutional Ethical Committee approval. All in-patients prescribed with anti-epileptic drugs in the pediatric, general medicine and nephrology departments were selected. Result: A total of 150 patients were enrolled in the study and 253 antiepileptic drugs were prescribed. Male patients were more than female and the majority was in the age of 36-60 years.Generalised tonic-clonic epilepsy was the most common type followed by unclassified seizures. The most commonly prescribed drugs were phenytoin, Levetiracetam and Sodium Valproate. A lesser number of newer antiepileptic agents were used compared to older ones. The prevalence of monotherapy is high compared to dual therapy and polytherapy. Conclusion: The most commonly prerscibed antiepilptic drug is Phenytoin, followed by Levetiracetam. There was under utilisation of newer antiepilptics.The rate of adherence observed in this study was low, which highlights the pervasive and problematic degree of antiepileptic medication adherence. Polypharmacy can predispose to drug interactions, which result in the failure of drug therapy and an increase in the length of hospital stays.
Keywords: Antiepileptic drug, Drug utilisation pattern, Drug utilisation Review, Polytherapy, Drug interaction, Medication adherence.
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