EVALUATION OF ANTI DIARRHEAL ACTIVITY OF STEM BARK OF OROXYLUM INDICUM ON EXPERIMENTAL ANIMALS

Anjali Garg*, Vipin Kumar Gupta and Avnesh singh

ABSTRACT

Aim: The objective of this study was to assess the Anti-Diarrheal Activity of the stem bark of the Oroxylum Indicum plant in Wistar albino rats. Method: The animals for the test were starved for 24 hours before experiments but were allowed free access to water. The animals for the experiment were divided into a normal control group, standard control group, stembark extract control-1group, and stembark control-2group, containing five rats in every group.
The animals were treated as follows:
Group-I: Control (normal saline solution, orally).
Group II: Castor oil-induced diarrhoeal group(Castor-oil, orally)
Group-III: Standard treated(Loperamide 3mg/ kg, orally).
Group-IV: Diarrhea+Ethanolic extract of Oroxylum Indicum stem bark 250mg/kg, orally.
Group-V: Diarrhea+Ethanolic extract of Oroxylum Indicum stem bark 500mg/kg, orally.
Later 30minutes after the given above cure the diarrhea is produced through using oral administration of 0.2ml of castor oil to each rat.
Every rat is kept in the house in a separate cage, the floor of the cage is lined with blotting paper. Every hour changed the lining of the floor.
Observed continues for four hrs, at the time of observations time the no. of total fecal yield and the statistics of diarrhea feces are noted of the rats. Results: The administration of the 250 mg/kg dosage of stem bark of the Oroxylum Indicum plant significantly exhibits Anti-Diarrheal effects, when compared to the ethanol group. Conclusion: The Oroxylum Indicum stem bark ethanolic extract showed anti-diarrhoeal action in the different models of diarrhoeal provisional rats. The Oroxylum Indicum stem bark ethanolic extracts suggestive reduction of the momentum of charcoal-meal by the abdominal and tool lower the occurrence of evacuation and feces stools. Likely the stem bark ethanolic extracts of Oroxylum Indicum prevent significantly PGE2-induced enter polling. Both stem bark ethanolic extracts of Oroxylum Indicum at the different dosages of 250mg/kg and 500mg/kg display unique pharmacological results besides diarrhea. Soon behalf of these observations and evaluations we can say that Oroxylum Indicum stem bark has anti-diarrhoeal action. It can be assumed that Oroxylum Indicum stem bark extract might be a possible spring for the new chief detection of the development of anti-diarrhoeal medicine.

Keywords: Castor Oil, Enterpooling, And Gastrointestinal.