BIOSYNTHESIS OF MAGNESIUM OXIDE NANOPARTICLES VIA KALANCHOE PINNATA: NOVEL UTILIZATION AS ANTIBACTERIAL, ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL

Rajakumari R.*, Gopi G., Jolly Oswin I., Akhilesh S. and Raghu P.

ABSTRACT

This research project delves into the multifaceted properties of magnesium oxide nanoparticles synthesized through a green method using fresh leaves of the Kalanchoe pinnata plant. The study meticulously characterizes these nanoparticles employing UV spectroscopy, dynamic light scattering (DLS), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR). The synthesized nanoparticles exhibit promising antibacterial attributes against both gram-positive and gram-negative bacterial strains. The evaluation of antibacterial activity reveals a noteworthy potential for applications in combating bacterial infections. Additionally, the nanoparticle's antioxidant properties are assessed through 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Phosphomolybdenum (PM) assays, showcasing their competence in scavenging free radicals and thereby contributing to potential therapeutic applications. Furthermore, the study explores the anti-inflammatory aspects of the green-synthesized magnesium oxide nanoparticles through the protein denaturation method. This investigation sheds light on the nanoparticles' capability to mitigate inflammation, offering insights into their potential as anti-inflammatory agents. The research amalgamates the realms of nanotechnology, biomedicine, and plant-based synthesis, paving the way for future developments in environmentally friendly nanoparticle synthesis and their diverse applications in medicine and healthcare.

Keywords: Green synthesis, Kalanchoe pinnata, MgONPs-KP, Antibacterial, In-Vitro Antioxidant, Anti-inflammatory.