A REVIEW ON BUCCAL PATCH: A MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM
A. V. Shelke*, S. S. Kulkarni and K. R. Biyani
Buccal route is an attractive route of administration for systemic drug delivery and it leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism provides high bioavailability. Drug actions can be improved by developing new oral drug delivery systems such as the mucoadhesive buccal drug delivery system. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. However, buccal patch offers greater flexibility and comfort than the other devices. Mucoadhesive buccal patches are a type of dosage form that uses controlled release to distribute drugs over a longer period of time. These patches often assist drugs in bypassing the liver's first pass processing and entering the systemic circulation directly. This article provides an information on buccal patches advantages, disadvantages, ideal characteristics and basic components of mucoadhesive buccal patches.
Keywords: Buccal patches, Mucoadhesion, Buccal drug delivery, oral mucosa.
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