EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

EVALUATION AND FORMULATION OF ANTIFUNGAL ACTIVITY OF DRAGON BLOOD EXTRACT AND INORGANIC SALTS ON DERMATOPHYTOSIS AND CANDIDIASIS

Mokhtar Abd Hafiz Al-Ghorafia* and Mahmoud Mahyoob Alburyhib

ABSTRACT

Introduction: Fungal infections, particularly dermatophytosis and candidiasis, pose significant challenges, especially in tropical and subtropical regions. Aim: This study aimed to assess the antifungal activity of Dragon's blood extract and inorganic salts and develop an effective and affordable pharmaceutical formulation for treating these infections. Methods: A study at the National Center of Public Health Laboratories in Sana'a from December 2021 to May 2022 collected clinical samples aseptically. It identified dermatophytes and C. albicans through KOH microscopic examination and culture on SDA. Antifungal susceptibility testing of Dragon blood extract, inorganic salts solutions, and formulation cream showed strong activity against Candida albicans and dermatophyte strains. Positive controls (Miconazole, Ketoconazole, Fluconazole, and Nystatin) also exhibited significant antifungal activity. Results: The Dragon blood extract and inorganic salts showed significant antifungal activity at different concentrations against M. audouinii, M. canis, T. violaceum and C. albicans with inhibition zone ranging from 14mm to >30mm. An oil in water (O/W) emulsion based cream was formulated. These results suggest the potential of Dragon's blood extract and inorganic salts as effective antifungal agents for dermatophytosis and candidiasis. Previous research has also highlighted the antimicrobial and antioxidant properties of the resin extracts, reaffirming their potential for pharmaceutical applications. Conclusion: The study indicates that Dragon's blood extract, inorganic salts, and the formulated cream have strong antifungal activity, making them potential candidates for alternative antifungal agents. The findings support the potential therapeutic and pharmaceutical applications of these natural compounds for combating fungal infections.

Keywords: Evaluation, Formulation, Antifungal Activity, Dragon Blood Extract, Inorganic Salts, Dermatophytosis, Candidiasis.

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