HISTOPATHOLOGICAL SPECTRUM OF OVARIAN NEOPLASMS DIAGNOSED IN A NATIONAL CANCER INSTITUTE OF EASTERN INDIA

*Dr. Prachi Kukreja, Dr. Kaushambi Chakraborty, Dr. Srabanti Hajra and Dr. Saunak Mitra Mustafi

ABSTRACT

Purpose: Ovarian neoplasms are the seventh most common malignant tumours diagnosed worldwide in women.[1] Histopathological examination being mainstay of diagnosis determines the prognosis and behavior of tumour. We have conducted this study to explore more about the diversity of the primary ovarian tumours and correlate histomorphological features with immunohistochemistry (IHC) profile. Methods: A total of 53 cases of ovarian masses were studied. Histopathological features for each haematoxylin and eosin stained section were studied and further evaluation with immunohistochemistry was done. Results: A total of 53 specimens of ovarian masses were obtained from patients. On histopathological examination, majority of tumours were malignant with surface epithelial tumours being the most common histological type. In them High grade serous carcinoma was the most common subtype. The next common histological types were germ cell tumours and sex cord stromal tumours. Immunohistochemistry was done for all the cases. PAX8, WT1, p53 were positive in all cases of High grade serous carcinomas. Conclusion: Histopathological examination being the mainstay of diagnosis helps in early diagnosis, staging and determination of prognosis. Thus in our study we have tried to increase the understanding about the histopathological spectrum of ovarian neoplasms and their distribution according to the histological subtype.

Keywords: Ovary, Ovarian Neoplasms, Surface epithelial tumours, Serous carcinoma.