EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

A RANDOMIZED CONTROLLED PROSPECTIVE STUDY OF AWARENESS UNDER GENERAL ANAESTHESIA COMPARING TWO DIFFERENT MAC VALUES OF DESFLURANE

*Dr. Lavanya P. Ram and Dr. Arpita Thakore

ABSTRACT

Background and Aim: Several studies have been conducted on awareness and the MAC required to prevent awareness during anesthesia. Our aim is to study the depth of anesthesia with 0.7 MAC and 1 MAC and assess awareness post operatively using BRICE questionnaire. Methodology: A prospective randomized controlled study was conducted for three years in a tertiary care hospital. A total of 256 patients who were scheduled for undergoing laparoscopy surgeries with duration limited to less than 2 hours were selected and divided them equally into two groups, the first and second groups were administered 0.7 and 1 MAC respectively and depth of anesthesia monitored with BIS Quatro sensor monitor (Covidien medical systems).
Group A(N=136) with MAC of desflurane 0.7 and BIS 40-60
Group B(N=120) with MAC of desflurane 1 and BIS 40-60.
Post-op awareness was assessed using the BRICE questionnaire.
Results: There were no observed statistical differences in both the groups regarding age, sex, body weight, height and comorbidities. No statistical difference in basal heart rate, SBP, DBP, MAP, SPO2. No awareness was seen in patients of both the groups. Volume of desflurane consumed in first hour was 25+/- 3 ml for group A with 0.7 MAC and 40+/- 5 ml in group B with 1 MAC which was statistically significant. The baseline BIS value for both groups is 92-99. The minimum BIS value attained was 40 in group A, 24 in group B. Conclusion: No awareness seen in either of the groups. No statistically significant differences in HR, SBP, DBP, MAP, SPO2. Volume of desflurane consumed in first hour was significantly lesser in 0.7 MAC Group and BIS value levels were maintaining between 40-60.

Keywords: 0.7 MAC, awareness, BIS, BRICE questionnaire, desflurane. -Question: Is 0.7 MAC good enough to prevent awareness? -Findings: Yes. It prevents awareness and provides hemodynamic stability like 1 MAC. -Meaning: Lesser MAC is enough to prevent awareness dur

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