EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF SCHIFF BASE AND ITS METAL COMPLEXES

Indu Singh* and Arun Kumar

ABSTRACT

The synthesis of a series of some novel Schiff base complexes of Cu (II), Ni (II), Co (II), Cd (II) and Zn (II) with a tetradentate Schiff base has been achieved by the reaction of 5-phenyl-1,3,4-thiadiazol-2-amine with 4-ethoxy-3-hydroxybenzaldehyde in ethanol under refluxing condition. The melting points were determined in open glass capillaries tubes. Purity of the compounds was checked by thin layer chromatography (TLC) on silica gel G plates and spots were located by using iodine chamber. All the newly synthesized metal complexes and ligand were characterized on the basis of elemental analysis, IR and 1HNMR spectral studies. All compounds were screened for their antifungal activity against A. niger C. albicans and C. krusei using fluconazole as a standard drug. It has been found that metal complexes show enhanced antifungal activity as compared to ligand.

Keywords: Co, Cu Ni, Cd and Zn complexes, Schiff base, antifungal activity, Fluconazole.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing