EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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ISSN 2394-3211

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ICV - 79.57

Abstract

ULTRASONOGRAPHIC RENAL STUDY OF TRYPANOSOMA BRUCEI INFECTED DOGS PRESENTED TO UNIVERSITY OF NIGERIA VETERINARY TEACHING HOSPITAL, NSUKKA

C. S. Ukwueze* and P. O. Akpa

ABSTRACT

This study was conducted to assess the renal status of Trypanosoma brucei infected dogs using ultrasonography and correlate it with kidney function test. A total of eighteen (18) Nigerian local breeds of dogs of both sexes, weighing between 6-10 kg were used for the study. Group I comprised of nine clinically Trypanosoma brucei infected dogs selected at the outpatient Department of the University of Nigeria Veterinary Teaching Hospital (UNVTH) and group II was nine the apparently healthy dogs. The uninfected group showed a thin echogenic line representing the capsule. The renal cortex was hypo echoic and finely granular structure. The renal medulla was anechoic and the renal pelvis was seen as an irregular echogenic mass at the hilus of the kidney. The infected group showed more echogenic mass in the renal pelvis and cortical region as well as thickening of capsule and reduction of size. The left and right kidney of the trypanosome infected group showed significant reduction (p<0.05) in volume compared to the uninfected group. The mean kidney volume of left and right of the uninfected group were 44.54 ± 3.48 cm3 and 47.39 ± 47.39 cm3 respectively, whereas for the trypanosome infected dogs, the mean kidney volume of the left and right kidney was 26.08 ± 17cm3 and 27.97 ± 3.66cm3, respectively. The mean blood urea nitrogen (BUN) and Creatinine (CRT) levels differed significantly (p<0.05). The mean BUN of infected and uninfected groups was 15.79 ± 9.42 and 7.70 ± 1.95, while CRT was 0.71 ± 0.20 and 0.47 ± 0.15 respectively for the infected and uninfected group. From this study ultrasonography showed the renal morphology, which ultimately represents a better prognosis for sick dogs, particularly on the guidance of therapeutic procedures to be employed and ultrasonograhic images can be correlated with kidney function test as they all point towards the functionality of the kidneys.

Keywords: Ultrasonography; Kidneys; Trypanosoma brucei; Dogs.

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