INFORMATIVE REVIEW OF LAYERED TECHNOLOGY OF TABLET- AN EMERGING INNOVATION IN ORAL DRUG DELIVERY SYSTEM

Mahabub Alam and Khurshid Jahan*

ABSTRACT

Oral route is most popular method of drug administration. Tablets are designed to deliver a precise dosage to a particular location in the body. They can also be given sublingually, buccally, rectally, or intravaginally. In addition to convenience, it has the benefit of improved absorption. Tablet is the most commonly utilized dosage form because of its durability and patient acceptability. These dosage forms stand out and are preferred over other forms due to their superior aesthetic qualities, such as color, texture, mouth feel, and flavor masking capabilities. Layered tablets typically increase patient compliance and lower production costs in half. Drugs with release boosters, fillers, or numerous dosages of the same drug are all examples of layered technology. This technology usually contains two to three APIs or APIs along with functional or nonfunctional placebo layers. Layered tablets provide more promise for improved patient outcomes and continue to be production-friendly. Comparing multi-layer tablets to conventional immediate-release reveals many significant advantages. By streamlining dosing regimens in combination therapy, the use of such solid oral dose forms increases patient compliance day by day. This study reviews the primary advantages of the layer stressing its key advantages as an oral dosage form as well as outlining its current difficulties and strides in product quality and manufacturing process improvement.

Keywords: Bilayer tablet, combination drugs, incompatible, multi-layered tablet, drug release kinetic.