A REVIEW ON RECENT ADVANCEMENTS IN COLON TARGETED DRUG DELIVERY SYSTEM

Srikrishna T., Y. Prapurnachandra, P. Venugopalaih, T. Thulasi*, K. Harika, L. Nichitha, O. Nikhil and J. Chandrika

ABSTRACT

Colon-specific systems might also allow oral administration of peptide and protein drugs, which are normally degraded in the upper parts of the gastrointestinal tract. The treatment of large intestine (colon) disorders such as colon cancer, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) i.e. Ulcerative colitis and Crohn's disease, Diverticulitis, and other colon diseases where a high concentration of the active therapeutic agent is required may be efficiently achieved by colon-specific delivery. Prodrugs, pH and time-dependent systems, and microbial triggered drug delivery systems are examples of primary techniques for colon-specific drug delivery (CDDS). In terms of achieving in-vivo drug delivery, newly developed CDDS, which includes pressure-controlled colonic delivery capsules (PCDCS) and osmotic controlled drug delivery, are unique site specificity and feasibility of the manufacturing process. The goal of this analysis is to provide extensive insight into the many colon disorders and tactics used to selectively target therapeutic agents to the colon. The colon is a site where both local and systemic medication delivery can occur. If medications could be targeted specifically on the colon, treatment might be considerably more effective. The colon target drug delivery system has grown in popularity not just for treating local disorders but also for systemic delivery of proteins, therapeutic peptides, anti-asthmatic medicines, antihypertensive medications, and antidiabetic compounds. However, recent attempts have been made to develop colon-specific delivery systems with increased site specificity and variable drug release kinetics to meet a variety of therapeutic demands. The goal of this review is to provide extensive insight into both traditional and novel techniques to targeting therapeutic medicines precisely to the colon.

Keywords: Colon-specific drug delivery, Colon cancer, Conventional, therapeutic peptides and New approaches.