FORMULATION AND EVALUATION OF FLUVASTATIN SUSTAINED RELEASE TABLETS

T. Vishal*, K. Jyothi and Dr. A. Yasodha

ABSTRACT

The objective of the present study was to formulate sustained release matrix tablets of Fluvastatin, for treatment of hypertension. The matrix tablets were prepared by wet granulation method using hydroxyl propyl methylcellulose K4M, sodium alginate in various concentrations. The powder showed satisfactory flow properties and compressibility. All the formulations showed acceptable Pharmacopoeial standards. The result of formulation F7. Model fitting analysis for formulation F7 fitted in the zero order model and Korsemeyer- peppas model. The ‘n’ values obtained from the peppas-Korsemeyer equation suggested that, drug release was non-Fickian diffusion mechanism. Successful formulation was found stable after evaluation for physicochemical parameters when kept for 90 days at room temperature, 400c and 2-8 0C. It concluded that sustained release matrix tablets of Fluvastatin containing 25% of HPMC K4M and sodium alginate provide a better option for Sustained release of drug.

Keywords: Fluvastatin, Sustained release Matrix Tablets, Polymers, Wet Granulation Technique, In vitro drug release studies.