NEUROPHARMACOLOGICAL & NEUROPROTECTIVE EFFECTS OF METHANOLIC EXTRACT OF LEAVES OF SESBANIA GRANDIFLORA IN RATS

*Ch. Lochana, M. Ganesh Kumar, Dr. K. Atchuta Kumar, B. Joshna and N. Geetha Rani

ABSTRACT

The methanolic extract of leaves of Sesbania Grandiflora was evaluated for its neuroprotective activity. Preliminary phytochemical analysis revealed the presence of alkaloids, carbohydrates, saponins, glycosides, protein and amino acids, phenolic compounds. The present investigation of the methanolic extract of leaf of Sesbania Grandiflora produced central inhibitory effect in mice and rats. Behavioural pharmacology field makes the concepts that are derived from pharmacology and psychology to study behaviour in animal models. The present study shows that the methanolic extract of leaf of Sesbania Grandiflora protected some of the animals against seizures induced by maximal electroshock. Antiepileptic drugs which inhibit voltage-dependent Na+ channels, such as phenytoin can prevent MES-induced tonic extension. In MES‐induced convulsion animals represents grandmal type of epilepsy. It has often been stated that antiepileptic drugs that block MES‐induced tonic extension phase act by blocking seizure spread. Moreover, MES‐induced tonic extension phase can be prevented either by drugs that inhibit voltage‐dependent Na+ channels, such as phenytoin, valproate, felbamate and lamotrigine or by drugs that block glutaminergic excitation mediated by the N- methyl‐ D‐Aspartate (NMDA) receptor such as felbamate. Our conclusion, investigation suggests that methanolic extract of powdered leaves of Sesbania Grandiflora. Which possess potent neuroprotective effects in rats & mice.

Keywords: Neuropharmacological Effects, Methanolic Extract, Leaves Of Sesbania Grandiflora, Rats & Mice.