FEATURES OF THE EXPRESSION OF MOLECULAR BIOMARKERS OF POLYCYSTIC OVARY SYNDROME IN WOMEN WITH INFERTILITY

*Zufarova Sh A., Shokirova S. M. and Ismailova A. A.

ABSTRACT

The aim of the research was to study the state of molecular markers depending on the clinical course of polycystic ovary syndrome in women with infertility. Material and Research Methods. The material is presented by three groups of women: Group 1 – 64 women with non-endocrine factors of infertility (tubal-peritoneal and endometriosis) with the absence of tumor-like formations or functional ovarian cysts; Group 2 – 48 women with polycystic ovary syndrome who became pregnant after treatment and group 3 – 96 women with infertility due to polycystic ovary syndrome. The studies were carried out using immunohistochemical analysis on histological material of the ovaries of women with infertility using test systems produced by Novocastra. The results obtained and their Discussion. When comparing clinical, laboratory and molecular data, a proliferation pattern is visible, which is characterized by three main types of expression. Conclusions: Women in group 1 are characterized by a predominance of moderate expression of Ki-67 in 68% of cases over high and moderate expression of p53 and Ki-67, which indicates slight hyperplasia and proliferation. Women in group 3 were characterized by a predominance of high and moderate expression of Ki-67 in 49% and 45% of cases over high and moderate expression of p53, which indicates more pronounced hyperplasia and proliferation in the ovarian tissue. And women of group 2 are characterized by a predominance of moderate expression of Ki-67 in 51% of cases over high and moderate expression of p53, which indicates significantly pronounced hyperplasia and proliferation in the ovarian tissue.

Keywords: polycystic ovary syndrome, infertility in women, endocrine disorders, molecular markers of proliferation and ovarian hyperplasia.