EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF LERCANIDIPINE HYDROCHLORIDE

Juberia Arshi, Sangu Manasa, *Dr. Shaik Shabbeer and Dr. Knv Rao

ABSTRACT

Floating Lercanidipine Hydrochloride microparticles using polymer ethyl cellulose, HPMC, Poly vinyl pyrrolidine and Eudragit RS 100 was developed by solvent evaporation method and it was found to be a suitable floating oral drug delivery system in terms of particle size distribution, drug loading capacity and Sustained release Lercanidipine Hydrochloride microparticles obtained was spherical in shape, discrete and free flow in nature. Polymer-drug ratio influence the particle size as well as drug release pattern of microsphere. Entrapment efficiency of drug loaded batches F1 to F9 were determined and it was found that F2 and F9 had a better drug entrapment efficiency of 95% and 96% Drug loading efficiency was better with F9 showed 96%. In-vitro drug release from all the formulations was found to be slow and sustained over the period of 8 hours was found to be 96.89%.

Keywords: Lercanidipine hydrochloride, HPMC, microsphere, In-vitro.

[Full Text Article] [Download Certificate]