THE EFFECT OF BISOPROLOI AS FAST DISSOLVE SUBLINGUAL TABLET ON THE HEART RATE OF STRESSED RABBITS

Ahmed Mohamed Alsabati, Abdalwali Ahmed Saif and Esmail Abdualkhaleq Mohammed*

ABSTRACT

The hormone adrenaline, also known as epinephrine, is produced by the adrenal glands and is essential for the body's "fight or flight" response. Studies show that the β -blocker drug Bisoprolol lowers the sympathetic nervous system's activation brought on by stress by blocking the release of adrenaline via the mediate route. The study investigates the impact of selective β1 blockers (Bisoprolol fast dissolve sublingual tablets, 10 mg) on rabbits' heart rates while they are subjected to physical stress. 18 rabbits were individually subjected to five minutes of physical stress in a lab setting. In a randomized controlled crossover study, each rabbit received one of three treatments: no stress exposure and no treatment (control group- treatment-1); stress exposure for five minutes and no treatment (treatment-2); and stress exposure for five minutes and treatment with bisoprolol fast dissolve tablets (treatment-3). Before and after being exposed to stress, the heart rate was recorded. Treatment 3 demonstrated a substantial reduction in rabbits' heart rates following treatment (p = 0.5) when compared to the control group. Based on results obtained, Bisoprolol fast-dissolving sublingual tablets, can prevent hearts from beating faster when they stressed or exercised.

Keywords: Heart Rate Variability, Super disintegrant, Fast Dissolve Sublingual Tablet, Heart Rate, Autonomic Nerves System, Bisoprolol Fumarate.