SYSTEMIC SCLEROSIS- A CASE REPORT

Basireddy Manjeera*, Santosh Kannan, Dr. Priyanka M. and Dr. K. V. Giriraja

ABSTRACT

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs associated with vascular injury and immune system dysregulation. This case report details of the 55 year old female who was diagnosed with systemic sclerosis on cyclophosphamide treatment, who is a known case of type 2 diabetes mellitus on oral hypoglycaemic drugs medications for 10 years and was also diagnosed with ductal carcinoma of right breast status post modified radical mastectomy 7 years back, came with recurrent episodes of vomiting, loose stools and pain abdomen. This patient was advised for HRCT THORAX to rule out lung fibrosis which revealed extensive honeycombing involving all lobes suggestive of interstitial lung disease possible secondary to systemic sclerosis. Immunological studies were done for the breast carcinoma; RNA – POLYMERASE ANTIBODY IgG was tested positive. Hence this article is adding to the evidence of the relation between systemic sclerosis, carcinoma and RNA- polymerase antibody (IgG).

Keywords: Systemic sclerosis, RNA, polymerase antibody, Carcinoma.